CS202210140_289
CGE_288 (CS202210140_289)
Hierarchy: CS202210140_486 > CS202210140_289
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_289
Labelset: Cluster (Rank: 1)
Parent Cell Set: CGE interneuron (CS202210140_486)
Cell Ontology Term: lamp5 GABAergic cortical interneuron (CL:4023011)
Rationale: Supported by marker expression and annotation transfer from MTG. More numerous in primates and molecularly similar to hippocampal interneurons
| Rationale DOIs |
|---|
| https://doi.org/10.1038/s41586-020-2781-z |
| Marker Genes |
|---|
| FOXG1 |
| NR2F1 |
| DLX1 |
| LAMP5 |
| LHX6 |
| GAD2 |
Transferred annotations:
| Transferred cell label | Source taxonomy | Source node accession | Algorithm name | Comment |
|---|---|---|---|---|
| Lamp5 | https://purl.brain-bican.org/taxonomy/AIT_MTG/AIT_MTG.json | CrossArea_subclass:89f956fe2e | We performed PCA (50 components) on our full dataset, trained a random forest classifier (scikit-learn, class_ weight=‘balanced’, max_depth=50) on the MTG labels, and then predicted labels for all cells. We labeled each cluster with the mode of its constituent cells if two conditions were met: more than 0.8 of predicted labels matched the mode, and the mean probability of these pre- dictions was greater than 0.8. |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 288 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CBLN CCK CHGA CHGB CORT CRH IGF NAMPT NUCB NXPH SCG UBL proSAAS |
| Subtype auto_annotation | INT-LAMP5 |
| Transferred MTG Label | Lamp5 |
| Top three regions | Cerebral cortex: 70.6%, Amygdala: 13.7%, Hippocampus: 6.3% |
| Top three dissections | Human M1C: 7.3%, Human MTG: 5.0%, Human MEC: 4.7% |
| Top Enriched Genes | HAPLN1, AC137770.1, LINC00298, AC132803.1, KIT, PKP2, EYA4, ROR2, NXPH2, GRPR |
| Number of cells | 24831.0 |
| DoubletFinder score | 0.014070101 |
| Total UMI | 14227.45951 |
| Fraction unspliced | 0.665533011 |
| Fraction mitochondrial | 0.008214529 |
| H19.30.002 | 8063.0 |
| H19.30.001 | 8313.0 |
| H18.30.002 | 7588.0 |
| H18.30.001 | 867.0 |
| Fraction cells from top donor | 0.334783134 |
| Number of donors | 4.0 |
| subcluster_id | None |