CS202210140_262
MGE_261 (CS202210140_262)
Hierarchy: CS202210140_484 > CS202210140_262
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_262
Labelset: Cluster (Rank: 1)
Parent Cell Set: MGE interneuron (CS202210140_484)
Cell Ontology Term: pvalb GABAergic cortical interneuron (CL:4023018)
| Rationale DOIs |
|---|
| https://doi.org/10.1038/s41586-020-2781-z |
| Marker Genes |
|---|
| FOXG1 |
| NR2F1 |
| DLX1 |
| LHX6 |
| GAD2 |
| PVALB |
Transferred annotations:
| Transferred cell label | Source taxonomy | Source node accession | Algorithm name | Comment |
|---|---|---|---|---|
| Pvalb | https://purl.brain-bican.org/taxonomy/AIT_MTG/AIT_MTG.json | CrossArea_subclass:5bcef2988c | We performed PCA (50 components) on our full dataset, trained a random forest classifier (scikit-learn, class_ weight=‘balanced’, max_depth=50) on the MTG labels, and then predicted labels for all cells. We labeled each cluster with the mode of its constituent cells if two conditions were met: more than 0.8 of predicted labels matched the mode, and the mean probability of these pre- dictions was greater than 0.8. |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 261 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CCK CHGA CHGB CORT IGF NAMPT NMU NPPC NUCB NXPH PNOC SCG TAC UBL VGF proSAAS |
| Subtype auto_annotation | INT-PVALB |
| Transferred MTG Label | Pvalb |
| Top three regions | Cerebral cortex: 95.5%, Hippocampus: 1.4%, Basal forebrain: 1.4% |
| Top three dissections | Human M1C: 13.2%, Human MTG: 6.5%, Human A29-A30: 4.8% |
| Top Enriched Genes | TCIM, RNF144B, LRRC38, ADAMTS17, PRDM1, KCNS3, MYO5B, RGS5, OSTN, LHX6 |
| Number of cells | 21457.0 |
| DoubletFinder score | 0.021885961 |
| Total UMI | 21126.03439 |
| Fraction unspliced | 0.700674421 |
| Fraction mitochondrial | 0.007369133 |
| H19.30.002 | 6962.0 |
| H19.30.001 | 6173.0 |
| H18.30.002 | 7369.0 |
| H18.30.001 | 953.0 |
| Fraction cells from top donor | 0.343431048 |
| Number of donors | 4.0 |
| subcluster_id | None |