CS202210140_254
MGE_253 (CS202210140_254)
Hierarchy: CS202210140_484 > CS202210140_254
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_254
Labelset: Cluster (Rank: 1)
Parent Cell Set: MGE interneuron (CS202210140_484)
Cell Ontology Term: sst GABAergic cortical interneuron (CL:4023017)
Rationale: Exclude ADARB2 because SST is expressed in some LAMP5-LHX6 interneurons
| Rationale DOIs |
|---|
| https://doi.org/10.1038/s41586-020-2781-z |
| Marker Genes |
|---|
| FOXG1 |
| NR2F1 |
| DLX1 |
| LHX6 |
| GAD2 |
| SST |
Transferred annotations:
| Transferred cell label | Source taxonomy | Source node accession | Algorithm name | Comment |
|---|---|---|---|---|
| Sst | https://purl.brain-bican.org/taxonomy/AIT_MTG/AIT_MTG.json | CrossArea_subclass:8fa477a378 | We performed PCA (50 components) on our full dataset, trained a random forest classifier (scikit-learn, class_ weight=‘balanced’, max_depth=50) on the MTG labels, and then predicted labels for all cells. We labeled each cluster with the mode of its constituent cells if two conditions were met: more than 0.8 of predicted labels matched the mode, and the mean probability of these pre- dictions was greater than 0.8. |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 253 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CBLN CCK CHGA CHGB CORT IGF NAMPT NMU NPY NUCB NXPH PNOC SCG SST TAC UBL VGF proSAAS |
| Subtype auto_annotation | INT-SST |
| Transferred MTG Label | Sst |
| Top three regions | Cerebral cortex: 81.1%, Amygdala: 8.4%, Basal forebrain: 6.1% |
| Top three dissections | Human M1C: 8.3%, Human FI: 6.3%, Human MTG: 5.3% |
| Top Enriched Genes | LINC00943, SCARA5, AC092353.2, AL450345.2, SST, LHX6, PAWR, TH, TLL2, NMU |
| Number of cells | 5703.0 |
| DoubletFinder score | 0.038952174 |
| Total UMI | 20145.85604 |
| Fraction unspliced | 0.734894763 |
| Fraction mitochondrial | 0.005552574 |
| H19.30.002 | 1727.0 |
| H19.30.001 | 2022.0 |
| H18.30.002 | 1690.0 |
| H18.30.001 | 264.0 |
| Fraction cells from top donor | 0.354550237 |
| Number of donors | 4.0 |
| subcluster_id | None |