CS202210140_250
MGE_249 (CS202210140_250)
Hierarchy: CS202210140_484 > CS202210140_250
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_250
Labelset: Cluster (Rank: 1)
Parent Cell Set: MGE interneuron (CS202210140_484)
Cell Ontology Term: sst GABAergic cortical interneuron (CL:4023017)
Rationale: Exclude ADARB2 because SST is expressed in some LAMP5-LHX6 interneurons
| Rationale DOIs |
|---|
| https://doi.org/10.1038/s41586-020-2781-z |
| Marker Genes |
|---|
| FOXG1 |
| NR2F1 |
| DLX1 |
| LHX6 |
| GAD2 |
| SST |
Transferred annotations:
| Transferred cell label | Source taxonomy | Source node accession | Algorithm name | Comment |
|---|---|---|---|---|
| Sst | https://purl.brain-bican.org/taxonomy/AIT_MTG/AIT_MTG.json | CrossArea_subclass:8fa477a378 | We performed PCA (50 components) on our full dataset, trained a random forest classifier (scikit-learn, class_ weight=‘balanced’, max_depth=50) on the MTG labels, and then predicted labels for all cells. We labeled each cluster with the mode of its constituent cells if two conditions were met: more than 0.8 of predicted labels matched the mode, and the mean probability of these pre- dictions was greater than 0.8. |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 249 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CBLN CCK CHGA CHGB CORT IGF NAMPT NMU NPY NUCB NXPH PNOC SCG SST TAC UBL VGF proSAAS |
| Subtype auto_annotation | INT-SST |
| Transferred MTG Label | Sst |
| Top three regions | Cerebral cortex: 61.8%, Hippocampus: 23.3%, Amygdala: 10.2% |
| Top three dissections | Human MEC: 10.2%, Human LEC: 7.8%, Human CA1C-CA3C: 6.1% |
| Top Enriched Genes | SCARA5, SST, ELFN1, DCN, ITGA1, PAWR, FAM89A, TNFSF15, MCUB, CRHBP |
| Number of cells | 5821.0 |
| DoubletFinder score | 0.038162801 |
| Total UMI | 21121.63907 |
| Fraction unspliced | 0.749661953 |
| Fraction mitochondrial | 0.004448194 |
| H19.30.002 | 1744.0 |
| H19.30.001 | 1715.0 |
| H18.30.002 | 2259.0 |
| H18.30.001 | 103.0 |
| Fraction cells from top donor | 0.38807765 |
| Number of donors | 4.0 |
| subcluster_id | None |