CS202210140_249
MGE_248 (CS202210140_249)
Hierarchy: CS202210140_484 > CS202210140_249
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_249
Labelset: Cluster (Rank: 1)
Parent Cell Set: MGE interneuron (CS202210140_484)
Cell Ontology Term: sst GABAergic cortical interneuron (CL:4023017)
Rationale: Exclude ADARB2 because SST is expressed in some LAMP5-LHX6 interneurons
| Rationale DOIs |
|---|
| https://doi.org/10.1038/s41586-020-2781-z |
| Marker Genes |
|---|
| FOXG1 |
| NR2F1 |
| DLX1 |
| LHX6 |
| GAD2 |
| SST |
Transferred annotations:
| Transferred cell label | Source taxonomy | Source node accession | Algorithm name | Comment |
|---|---|---|---|---|
| Sst | https://purl.brain-bican.org/taxonomy/AIT_MTG/AIT_MTG.json | CrossArea_subclass:8fa477a378 | We performed PCA (50 components) on our full dataset, trained a random forest classifier (scikit-learn, class_ weight=‘balanced’, max_depth=50) on the MTG labels, and then predicted labels for all cells. We labeled each cluster with the mode of its constituent cells if two conditions were met: more than 0.8 of predicted labels matched the mode, and the mean probability of these pre- dictions was greater than 0.8. |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 248 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CCK CHGA CHGB CORT IGF NAMPT NMU NPY NUCB NXPH PNOC SCG SST TAC UBL VGF proSAAS |
| Subtype auto_annotation | INT-SST |
| Transferred MTG Label | Sst |
| Top three regions | Cerebral cortex: 78.8%, Hippocampus: 12.5%, Amygdala: 5.0% |
| Top three dissections | Human V1C: 11.2%, Human M1C: 10.1%, Human MTG: 4.4% |
| Top Enriched Genes | HPGD, TAC1, FAM89A, AL450345.2, DCN, ALDH1A3, AC096751.2, CORT, BMP3, LHX6 |
| Number of cells | 2535.0 |
| DoubletFinder score | 0.068284682 |
| Total UMI | 22094.52702 |
| Fraction unspliced | 0.705161478 |
| Fraction mitochondrial | 0.005850942 |
| H19.30.002 | 708.0 |
| H19.30.001 | 768.0 |
| H18.30.002 | 910.0 |
| H18.30.001 | 149.0 |
| Fraction cells from top donor | 0.358974359 |
| Number of donors | 4.0 |
| subcluster_id | None |