CS202210140_241
MGE_240 (CS202210140_241)
Hierarchy: CS202210140_484 > CS202210140_241
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_241
Labelset: Cluster (Rank: 1)
Parent Cell Set: MGE interneuron (CS202210140_484)
Cell Ontology Term: sst GABAergic cortical interneuron (CL:4023017)
Rationale: Exclude ADARB2 because SST is expressed in some LAMP5-LHX6 interneurons
| Rationale DOIs |
|---|
| https://doi.org/10.1038/s41586-020-2781-z |
| Marker Genes |
|---|
| FOXG1 |
| NR2F1 |
| DLX1 |
| LHX6 |
| GAD2 |
| SST |
Transferred annotations:
| Transferred cell label | Source taxonomy | Source node accession | Algorithm name | Comment |
|---|---|---|---|---|
| Pvalb | https://purl.brain-bican.org/taxonomy/AIT_MTG/AIT_MTG.json | CrossArea_subclass:5bcef2988c | We performed PCA (50 components) on our full dataset, trained a random forest classifier (scikit-learn, class_ weight=‘balanced’, max_depth=50) on the MTG labels, and then predicted labels for all cells. We labeled each cluster with the mode of its constituent cells if two conditions were met: more than 0.8 of predicted labels matched the mode, and the mean probability of these pre- dictions was greater than 0.8. |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 240 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CBLN CCK CHGA CHGB CORT IGF NAMPT NMU NPPC NUCB NXPH PNOC SCG SST TAC UBL proSAAS |
| Subtype auto_annotation | INT-SST |
| Transferred MTG Label | Pvalb |
| Top three regions | Cerebral cortex: 92.3%, Amygdala: 3.0%, Hippocampus: 2.3% |
| Top three dissections | Human M1C: 10.5%, Human MTG: 7.6%, Human A40: 5.0% |
| Top Enriched Genes | AC011586.2, AC022905.1, MSR1, IL18R1, PRDM1, MYO5B, RGS5, CDKN2B-AS1, CMTM8, CDCA7 |
| Number of cells | 1327.0 |
| DoubletFinder score | 0.038675978 |
| Total UMI | 15338.85983 |
| Fraction unspliced | 0.722396385 |
| Fraction mitochondrial | 0.00994752 |
| H19.30.002 | 425.0 |
| H19.30.001 | 464.0 |
| H18.30.002 | 398.0 |
| H18.30.001 | 40.0 |
| Fraction cells from top donor | 0.349660889 |
| Number of donors | 4.0 |
| subcluster_id | None |