CS202210140_221
MSN_220 (CS202210140_221)
Hierarchy: CS202210140_481 > CS202210140_221
PURL: https://purl.brain-bican.org/taxonomy/CS202210140/CS202210140_neurons/CS202210140_221
Labelset: Cluster (Rank: 1)
Parent Cell Set: Medium spiny neuron (CS202210140_481)
Cell Ontology Term: direct pathway medium spiny neuron (CL:4023026)
Rationale: FOXG1 and GAD2 to restrict the annotation to inhibitory telencephalic neurons. FOXP1, DRD1 are canonical markers. OTOF is a good marker in the human data, previously described as an eccentric MSN marker. RGS9 and GPR88 from mouse auto-annotation
| Marker Genes |
|---|
| FOXG1 |
| SLC32A1 |
| FOXP1 |
| FOXP2 |
| OTOF |
| DRD1 |
| RGS9 |
| GPR88 |
Author annotation fields:
| Author annotation | Value |
|---|---|
| Cluster ID | 220 |
| Class auto_annotation | NEUR |
| Neurotransmitter auto_annotation | GABA |
| Neuropeptide auto_annotation | CBLN CCK CHGA CHGB NAMPT NUCB PDYN PENK SCG SST TAC UBL UCN VGF proSAAS |
| Subtype auto_annotation | MSN-D1 |
| Transferred MTG Label | None |
| Top three regions | Amygdala: 91.6%, Thalamus: 8.4%, Cerebral cortex: 0.0% |
| Top three dissections | Human CEN: 87.5%, Human VA: 6.4%, Human La: 2.6% |
| Top Enriched Genes | FAM9B, ISL1, AC010478.1, PTGDR, NPNT, EBF1, DRD1, MYO3A, LPL, GDNF-AS1 |
| Number of cells | 391.0 |
| DoubletFinder score | 0.048874961 |
| Total UMI | 38135.49872 |
| Fraction unspliced | 0.780738856 |
| Fraction mitochondrial | 0.008575176 |
| H19.30.002 | 5.0 |
| H19.30.001 | 12.0 |
| H18.30.002 | 374.0 |
| H18.30.001 | 0.0 |
| Fraction cells from top donor | 0.956521739 |
| Number of donors | 3.0 |
| subcluster_id | None |